Il SdKfz 250 fu secondo solo al SdKfz 251, e fu disegnato per una varietà di ruoli per fanteria, incluso il traino di armi anticarro e obici. Il primo modello entrò in servizio nel 1940 e fu usato nell’invasione della Francia; la produzione continuò fino al 1943 nella sua forma originale fino a quando la carrozzeria fu leggermente semplificata per agevolarne la produzione. Confrontandolo col 251, era relativamente piccolo, ed il modello base, il 250/1, era stato progettato come una trasporto truppe corazzato, per caricare un plotone e i comandanti di compagnia. Aveva una o due mitragliatrici, montate su un affusto girevole. Il 250/2 veniva utilizzato come postazione telefonica o veicolo da osservazione; il 250/3 (Leichter Funkpanzerwagen) aveva una antenna superiore a forma di rete di letto ed era un veicolo per radiocomunicazioni, lo stesso veicolo che Rommel utilizzava come postazione di comando, il Grief. Il 250/4 fungeva da avamposto da collegamento e osservazione aerea, mentre il 250/5 era un Leichter Beobachtungspanzerwagen

che caricava equipaggiamenti radio ed era usato come avamposto di osservazione. Il 250/6 era invece un trasporto-munizioni per armi da assalto, il 250/7 trasportava un mortaio da 80 mm e spesso trasportava i plotoni del battaglione Panzer Grenadier. Il 250/8 era munito di un cannone corto da 75 mm e il 250/9 aveva una torretta completa ed era a tutti gli effetti un’autoblinda semicingolata; il 250/10 ospitava un cannone anticarro da 37 mm, molto simile al 250/11 che aveva un cannone da 20 mm Schwere Panzerbusche 41 montato anteriormente.  La variante finale fu la 250/12, il Leichter Messtruppanzerwagen, progettato per portare pezzi d’artiglieria ed equipaggiato con periscopi da ricerca ed apparati di segnalazione. Dopo il 1943 fu richiesto un programma di semplificazione della struttura sia del 250 che del 251 per abbassare i costi e ridurre i tempi di produzione.

  The SdKfz 250 was second only to the SdKfz 251, and it was designed for a variety of infantry roles, including the towing of anti-tank guns and howitzers. The vehicle first entered service in 1940 and was used in the invasion of France, and production continued until 1943 in its original form until its body was slightly simplified to help production. Compared with the 251 it was relatively small, and the basic model, the 250/1, was designed as an armoured troop carrier to carry a platoon and company commanders. It had either one or two machine-guns fitted on a pivoted mount. The 250/2 was used as a telephone layer and as an observation vehicle, and the 250/3 (Leichter Funkpanzerwagen) had a bedstead frame aerial and was a radio vehicle, typified by Rommel's own personal command car, the Grief. The 250/4 was an air liaison and observation post vehicle, and the 250/5 was a Leichter Beobachtungspanzerwagen which carried radio equipment and was used as an observation post vehicle. The 250/6 was essentially an ammunition carrier for assault guns, and the 250/7 was a specialist 80 mm mortar carrier and often carried the heavy platoon of a Panzer Grenadier battalion. The 250/8 was armed with a 75 mm short gun, and the 250/9 had a complete turret assembly from the SdKfz 222 and was in all respects a half-tracked armoured car. The 250/10 housed a 37 mm PaK gun and had actually appeared as early as 1940. A similar 250/11 carried the 20 mm Schwere Panzerbusche 41 mounted in the front. The final variant was the 250/12, which was a Leichter Messtruppanzerwagen, designed for use with artillery and equipped with range-finding periscopes and signalling apparatus. After 1943 a rationalisation programme sought to simplify the superstructures of both the 250 and the 251 vehicles in order to reduce costs and cut down on production time. All this attempt managed to achieve was to disrupt the production of both vehicles at a time when they were most needed.